Resveratrol

gr4    grap grapeThe French and Mediterranean lifestyle are thought to be protective against coronary heart disease, especially their red wine consumption paired with a high-flavonoid diet (Ruf, 2004). Flavonoids provide the flavour and colour to most fruits and vegetables. Grapes contain numerous polyphenols, including flavonoids, as well as resveratrol. Polyphenols are in grape seeds as well as in the skin and stems.

Studies suggest resveratrol is protective against heart disease, has a body fat lowering effect and prevents neurodegeneration (brain degeneration), and helps wound healing (Potter et al., 2013;Penumathsa & Maulik, 2009; Alberdi et al., 2013).    

Research suggests daily resveratrol consumption is protective against heart disease as it inhibits the initiation of atherosclerosis.

Studies show that consuming resveratrol contributes to increased whole-body energy dissipation, which may help to explain the body fat lowering effect of this polyphenol antioxidant (Alberdi et al., 2013).

Additionally studies suggest resveratrol has a protective effect on Alzheimer’s disease (Chuanjun et al., 2013; Lu et al., 2013; Potter, 2013). The anti-oxidative enzymes in resveratrol have been suggested to scavenge oxidants to provide neuroprotection and have anti-inflammatory effect in the brain.

Animal studies suggests that resveratrol consumption assists in accelerating wound healing (Potter et al., 2013; Ismail et al., 2012)

Conclusion

The traditional Mediterranean diet was high in polyphenols, derived from vegetables and red wine, suggesting that dietary polyphenols are protective against heart disease. Consumption of red wine should be within the recommended limit and also grape juice has high sugar content. Additionally grape flavonoids (resveratrol) are available as a supplement (I like Morlife’s NuMe).

gReferences

Alberdi G, Rodríguez VM, Miranda J, Macarulla MT, Churruca I, Portillo MP (2013). Thermogenesis is involved in the body-fat lowering effects of resveratrol in rats. Food Chem;141(2):1530-5. doi: 10.1016/j.foodchem.2013.03.085. Epub 2013 Apr 13.

Chuanjun Lu , Yueyan Guo , Jun Yan , Zonghua Luo , Hai-Bin Luo , Ming Yan , Ling Huang, and Xingshu Li (2013) Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease. J. Med. Chem., Just Accepted Manuscript, DOI: 10.1021/jm400567s.

Ismail Yaman, Hayrullah Derici, Cemal Kara, Erdinc Kamer, Gulden Diniz, Ragip Ortac, Oya Sayin, (2012) Effects of resveratrol on incisional wound healing in rats, Surgery Today Surg Today. 2012 Dec 15. [Epub ahead of print]

Lu C, Guo Y, Yan J, Luo Z, Luo HB, Yan M, Huang L, Li X (2013). Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease. J Med Chem. [Epub ahead of print]

Penumathsa SV, Maulik N. (2009) Resveratrol: a promising agent in promoting Cardioprotection against coronary heart disease. Can J Physiol Pharmacol, 87(4):275-86. doi: 10.1139/Y09-013.grape1

Potter KA, Buck AC, Self WK, Callanan ME & Sunil S (2013). The effect of resveratrol on neurodegeneration and blood brain barrier stability surrounding intracortical microelectrodes, Biomaterials Volume 34, Issue 29, September 2013, Pages 7001–7015.

Ruf JC (2004). Alcohol, wine and platelet function. Biol Res;37(2):209-15.

OLYMPUS DIGITAL CAMERAgr7gr1

Comments are closed.